Panama City chewed us up and spit us out

We are not city people. We know this about ourselves and yet we still chose to drive in Panama City and stay at least one night.
Estúpidos Americanos!
The only piece of advice I can give is this: Invest in a portable navigation system or make sure the car you rent has one.
We have a portable device which we brought along after purchasing the Panama map off the Internet. Unfortunately, it let us down a few times. So much so, that at one point, my husband literally banged it against the dashboard a few times in his anger and frustration while saying a few choice words that I cannot repeat.
Thankfully, the system survived. Otherwise, there’s a very good chance we would still be driving around the streets of Panama City today.
Yes, we did make a couple of wrong turns only to end up in some very unsavory neighborhoods. On those occasions we quickly made a u-turn and made our escape. All those stories we heard about gringos ending up in such places only to be carjacked, thankfully did not happen to us.
We did eventually make it to our various destinations, Hotel Marparaiso, Miraflores Locks, Albrook Mall, Hotel Riande Aeropuerto, within and around the city at which point we drank heavily.